Human Amniotic Mesenchymal Stem Cells Inhibit aGVHD by Regulating Balance of Treg and T Effector Cells.

Ya GaoWeiru LiXiaoyin BuYing XuShengchun CaiJinman ZhongMeixue DuHaitao SunLiping HuangYongjian HeXiumei HuQifa LiuHua JinQian WangBaohong Ping

Published in: Journal of inflammation research (2021)

The NPG murine environment was capable of activating human T cells to produce aGVHD pathology to mimic aGVHD as in humans. The hAMSCs controlled aGVHD by decreasing inflammatory cytokine secretion within target organs by modulating the balance of Tregs and T effector cells in humanized mice.

Keyphrases

induced apoptosis
endothelial cells
mesenchymal stem cells
signaling pathway
cell cycle arrest
induced pluripotent stem cells
dendritic cells
regulatory t cells
pluripotent stem cells
endoplasmic reticulum stress
cell death
type diabetes
metabolic syndrome
type iii
high fat diet induced
wild type