Role of the NF-kB/parkin/vegfr-1 pathway associated with hypoxic-ischemic insult in germinal matrix samples of newborn infants.
Eliane Amaral GhirelliFelipe Paes Gomes da SilvaAlessandro Gonçalves Gomes OricilCaroline Busatta Vaz de PaulaSeigo NagashimaCarlos Frederico Oldenburg NetoEduardo StortiFernando Yochiteru Rolim SakiyamaRafael Martins KayanoRenata Rolim SakiyamaVinícius da Silva MoreiraVanessa Santos SotomaiorAnna Flávia Ribeiro Dos Santos MiggiolaroPublished in: Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo (2023)
The results suggest a direct involvement between the hypoxic-ischemic insult and NF-kB and VEGFR-1 markers since a decreased immunoexpression of these biomarkers was observed in asphyxiated patients. Furthermore, it is suggested that there was not enough time for VEGFR-1 to be transcribed, translated and expressed on the surface of the plasma membrane. This temporality can be observed in the relationship between NF-kB expression and the survival time of individuals who died within 24 hours, suggesting that this factor is essential for the production of VEGFR-1 and, therefore, to carry out the necessary remodeling effect to neovascularize the affected region.