Salvianolic acid C attenuates cerebral ischemic injury through inhibiting neuroinflammation via the TLR4-TREM1-NF-κB pathway.
Wenbo GuoXiaojing XuYulin XiaoJiatian ZhangPeiqiang ShenXiaoyan LuXiaohui FanPublished in: Chinese medicine (2024)
SalC attenuated cerebral ischemic injury by inhibiting neuroinflammation mediated by microglia, primarily through the TLR4-TREM1-NF-κB pathway. These findings provide valuable insights into the potential therapeutic benefits of SalC in ischemic stroke.
Keyphrases
- lps induced
- inflammatory response
- cerebral ischemia
- signaling pathway
- subarachnoid hemorrhage
- lipopolysaccharide induced
- toll like receptor
- nuclear factor
- brain injury
- blood brain barrier
- pi k akt
- immune response
- ischemia reperfusion injury
- traumatic brain injury
- oxidative stress
- atrial fibrillation
- cell proliferation
- spinal cord injury