Curcumin Analog CH-5 Suppresses the Proliferation, Migration, and Invasion of the Human Gastric Cancer Cell Line HGC-27.
Gabriel SilvaFelipe Teixeira LimaViviane SebaAna Laura Mendes LourençoThaise Graminha LucasBianca Vieira de AndradeGuilherme Silva TorrezanCarlos Roberto PolaquiniMarcelo Engracia GarciaLucélio Bernardes CoutoReinaldo Bulgarelli BestettiSuzelei de Castro FrançaAna Lúcia FachinLuis Octavio RegasiniMozart MarinsPublished in: Molecules (Basel, Switzerland) (2018)
Gastric cancer is one of the most frequent malignant tumors in the world. The majority of patients are diagnosed with metastatic gastric cancer, which has a low survival rate. These data reinforce the importance of studying the anticancer activity of new molecules with the potential to suppress gastric cancer metastasis. Curcumin is a well-studied compound that has demonstrated anti-metastatic effects. Here we investigated if CH-5, a curcumin derivative compound, has anti-metastatic properties in the human gastric cancer cell line HGC-27. Firstly, we found that CH-5 decreased viability and induced apoptosis in HGC-27 cells in a dose-dependent manner. Additionally, CH-5 suppressed the migration and invasion of HGC-27 cells by downregulating the expression and collagenase activity of matrix metalloproteinase 2 in a dose-dependent manner. In conclusion, CH-5 showed anticancer activities, including the induction of apoptosis, and the suppression of migration and invasion in HGC-27 cells, suggesting that CH-5 can be a lead molecule for the development of anti-metastatic drugs for gastric cancer therapy.
Keyphrases
- induced apoptosis
- endoplasmic reticulum stress
- signaling pathway
- cell cycle arrest
- oxidative stress
- room temperature
- squamous cell carcinoma
- small cell lung cancer
- endothelial cells
- cancer therapy
- cell death
- pi k akt
- end stage renal disease
- chronic kidney disease
- drug delivery
- poor prognosis
- induced pluripotent stem cells
- prognostic factors
- binding protein