Trps1 predicts poor prognosis in advanced high grade serous ovarian carcinoma.
Xiaojiang WangJiandong SunYue LiuZihang LinXia JiangYuhong YeChengyu LvXiuli LianWeiwei XuShanshan LuoShumin LiaoZhangting ChenShie WangPublished in: International journal of cancer (2024)
TRPS1 is aberrantly expressed in a variety of tumors, including breast, prostate, and gastric cancers, and is strongly associated with tumorigenesis or prognosis. However, the role of TRPS1 in high grade serous ovarian carcinoma (HGSC) is unknown. We investigated the relationship between TRPS1 expression and clinicopathology in HGSC patients. The tumor-related regulatory mechanisms of TRPS1 was explored through in vivo and vitro experiments. The results showed that TRPS1 was highly expressed in HGSC compared to normal tissues. It was also linked to the cell proliferation index Ki67 and poor prognosis. In vivo experiments showed that knockdown of TRPS1 could inhibit tumor growth. In vitro experiments, knockdown of TRPS1 inhibited the proliferation of ovarian cancer cells. TRPS1 exerted its regulatory role as a transcription factor, binding to the PSAT1 promoter and promoting the expression of PSAT1 gene. Meanwhile, PSAT1 was positively correlated with CCND1 expression. These results suggest that TRPS1 affects HGSC proliferation and cell cycle by regulating PSAT1 and thus CCND1 expression.
Keyphrases
- poor prognosis
- high grade
- long non coding rna
- cell cycle
- transcription factor
- cell proliferation
- low grade
- prostate cancer
- end stage renal disease
- gene expression
- signaling pathway
- dna methylation
- chronic kidney disease
- radiation therapy
- peritoneal dialysis
- squamous cell carcinoma
- pi k akt
- binding protein
- genome wide identification
- drug induced
- rectal cancer