Radiation nephropathy is a rare complication following total body irradiation (TBI) and peptide receptor radionuclide therapy (PRRT). Yttrium 90-DOTATOC (Y90) is a somatostatin analogue labelled with Y90 used for somatostatin-positive neuroendocrine tumours. Y90 is renally excreted and has a cumulative effect in the renal parenchyma Despite fractionation and co-administration of renoprotective intravenous amino acids, targeted radionuclide therapy can still be nephrotoxic. Rising adoption of PRRT has led to the re-emergence of radiation nephropathy. We report on three recent cases of insidious onset of progressive kidney dysfunction and biopsy-proven thrombotic microangiopathy following PRRT and TBI.
Keyphrases
- traumatic brain injury
- radiation induced
- amino acid
- multiple sclerosis
- neuroendocrine tumors
- severe traumatic brain injury
- oxidative stress
- high dose
- pet ct
- diabetic nephropathy
- mild traumatic brain injury
- radiation therapy
- ultrasound guided
- stem cells
- mesenchymal stem cells
- low dose
- drug delivery
- smoking cessation
- replacement therapy