Elevated serum IgG4 defines specific clinical phenotype of rheumatoid arthritis.
Le-Feng ChenYing-Qian MoJian-Da MaLing LuoDong-hui ZhengLie DaiPublished in: Mediators of inflammation (2014)
Our results showed that elevated sIgG4 in RA is common and disproportional to total IgG and RA with elevated sIgG4 may be a specific clinical phenotype with higher disease activity, higher level of autoantibodies, and poor response to methotrexate and leflunomide therapy.