DNA methylation and body mass index from birth to adolescence: meta-analyses of epigenome-wide association studies.
Florianne O L VehmeijerLeanne K KüpersGemma C SharpLucas A SalasSamantha LentDereje D JimaGwen TindulaSarah ReeseCancan QiOlena GruzievaChristian PageFaisal I RezwanPhilip E MeltonEllen NohrGeòrgia EscaramísPeter RzehakAnni HeiskalaTong GongSamuli T TuominenLu GaoJason P RossAnne P StarlingJohn W HollowayPaul YousefiGunn Marit AasvangLawrence J BeilinAnna BergströmElisabeth BinderLeda ChatziEva CorpeleijnDarina CzamaraBrenda EskenaziSusan EwartNatalia FerreVeit GroteDariusz GruszfeldSiri E HåbergCathrine HoyoKaren HuenRobert KarlssonInger KullJean-Paul LanghendriesJohanna LepeuleMaria C MagnusRachel L MaguirePeter L MolloyClaire MonnereauTrevor A MoriEmily OkenKatri RäikkönenSheryl Rifas-ShimanCarlos Ruiz-ArenasSylvain SebertVilhelmina UllemarElvira VerduciJudith M VonkCheng-Jian XuIvana V YangHongmei ZhangWeiming ZhangWilfried KarmausDana DabeleaBeverly S MuhlhauslerCarrie V BretonJari LahtiCatarina AlmqvistMarjo-Riitta JarvelinBerthold KoletzkoMartine VrijheidThorkild I A SørensenRae-Chi HuangSyed Hasan ArshadWenche NystadErik MelénGerard H KoppelmanStephanie J LondonNina HollandMariona BustamanteSusan K MurphyMarie-France HivertAndrea BaccarelliCaroline L ReltonHarold SniederVincent W V JaddoeJanine F FelixPublished in: Genome medicine (2020)
There were only minimal associations of DNA methylation with childhood and adolescent BMI. With the advancing age of the participants across childhood and adolescence, we observed increasing overlap with altered DNA methylation loci reported in association with adult BMI. These findings may be compatible with the hypothesis that DNA methylation differences are mostly a consequence rather than a cause of obesity.
Keyphrases
- dna methylation
- body mass index
- genome wide
- gene expression
- weight gain
- meta analyses
- childhood cancer
- depressive symptoms
- systematic review
- young adults
- type diabetes
- insulin resistance
- randomized controlled trial
- early life
- pregnant women
- high fat diet induced
- case control
- preterm birth
- pregnancy outcomes
- genome wide association