CD73; a key ectonucleotidase in the development of breast cancer: Recent advances and perspectives.
Anvar SoleimaniEskandar TaghizadehShirin ShahsavariYousef AminiHatam RashidpourEsmaeel AzadianArash JafariMohammad Reza ParizadehKazem MashayekhiMohammad SoukhtanlooMahmoud Reza JaafariPublished in: Journal of cellular physiology (2019)
Tumor cell invasion and metastasis are the definitive cause of mortality in breast cancer (BC). Hypoxia and pro-inflammatory cytokines upregulate the CD73 gene in the tumor microenvironment. Subsequently, CD73 triggers molecular and cellular signaling pathways by both enzymatic and nonenzymatic pathways, which finally leads to breast tumor progression and development. In this paper, we summarize current advances in the understanding of CD73-driven mechanisms that promote BC development and mortality. Furthermore, we evaluate the therapeutic potential of CD73 targeting in BC.
Keyphrases
- nk cells
- cardiovascular events
- signaling pathway
- risk factors
- cardiovascular disease
- genome wide
- type diabetes
- dna methylation
- poor prognosis
- endothelial cells
- oxidative stress
- coronary artery disease
- hydrogen peroxide
- gene expression
- long non coding rna
- single molecule
- cell proliferation
- epithelial mesenchymal transition
- cancer therapy
- transcription factor
- endoplasmic reticulum stress