Enhanced offspring predisposition to steatohepatitis with maternal high-fat diet is associated with epigenetic and microbiome alterations.

Umesh D WankhadeYing ZhongPing KangMaria AlfaroSree V ChintapalliKeshari M ThakaliKartik Shankar

Published in: PloS one (2017)

Our findings indicate that maternal HFD detrimentally alters epigenetic and gut microbiome pathways to favor development of fatty liver disease and its progressive sequelae.

Keyphrases

high fat diet
insulin resistance
adipose tissue
dna methylation
birth weight
gene expression
pregnancy outcomes
multiple sclerosis
metabolic syndrome
type diabetes
pregnant women
skeletal muscle
fatty acid