Expression pattern analysis of m6A regulators reveals IGF2BP3 as a key modulator in osteoarthritis synovial macrophages.

Yuheng LuHongbo ZhangHaoyan PanZhicheng ZhangHua ZengHaoyu XieJianbin YinWen TangRengui LinChun ZengDaozhang Cai

Published in: Journal of translational medicine (2023)

Our findings revealed the functions of m6A regulators in OA synovium and highlighted the association between IGF2BP3 and enhanced M1 polarization and inflammation in OA macrophages, providing novel molecular targets for OA diagnosis and treatment.

Keyphrases

knee osteoarthritis
binding protein
transcription factor
poor prognosis
oxidative stress
pi k akt
rheumatoid arthritis
single cell
cell proliferation
long non coding rna