Randomized, Controlled Trial of the FGF21 Analogue Pegozafermin in NASH.
Stephen CaldwellArun J SanyalKris V KowdleyDeepak L BhattRohit L LoombaJuan Pablo FriasPierre BedossaStephen A HarrisonDonald LazasRobert BarishMildred D GottwaldShibao FengGermaine D AgollahCynthia L HartsfieldHank MansbachMaya MargalitManal F AbdelmalekPublished in: The New England journal of medicine (2023)
In this phase 2b trial, treatment with pegozafermin led to improvements in fibrosis. These results support the advancement of pegozafermin into phase 3 development. (Funded by 89bio; ENLIVEN ClinicalTrials.gov number, NCT04929483.).