Urinary Catheter Colonization by Multidrug-Resistant Cedecea neteri in Patient with Benign Prostatic Hyperplasia.
Peter S GinnSerina B TartStephen M SharkadyDorothea K ThompsonPublished in: Case reports in infectious diseases (2018)
Cedecea neteri, a member of the Enterobacteriaceae family, has only been identified as a human pathogen in a few previous clinical cases, thus complicating assessment of this organism's pathogenicity and medical relevance. Documented infections attributed to C. neteri primarily involved bacteremia in severely immunocompromised patients. We report a rare case of urinary catheter colonization by a multidrug-resistant C. neteri strain in a patient of advanced age with benign prostatic hyperplasia and other chronic comorbidities. This C. neteri isolate was resistant or intermediate to second-generation cephalosporins, penicillins, and certain β-lactamase inhibitor/β-lactam combinations. Analysis of whole genome sequence information for a representative C. neteri strain indicated the presence of multiple open reading frames with sequence similarity to β-lactamases, including a chromosome-encoded AmpC β-lactamase and metallo-β-lactamases, consistent with the resistance phenotype of this bacterium. The presence of an AmpR homolog suggests that the C. neteriampC may be inducible in response to β-lactam exposure. Molecular insights into antibiotic resistance traits of this emerging opportunistic pathogen will be important for administering adequate antibiotic treatment to ensure favorable patient outcomes.
Keyphrases
- multidrug resistant
- gram negative
- benign prostatic hyperplasia
- lower urinary tract symptoms
- drug resistant
- acinetobacter baumannii
- rare case
- klebsiella pneumoniae
- end stage renal disease
- case report
- newly diagnosed
- endothelial cells
- chronic kidney disease
- ejection fraction
- prognostic factors
- escherichia coli
- minimally invasive
- candida albicans
- peritoneal dialysis
- pseudomonas aeruginosa
- copy number
- staphylococcus aureus
- cross sectional
- combination therapy
- replacement therapy
- induced pluripotent stem cells
- respiratory failure
- patient reported
- urinary tract infection
- social media