FOXA2 Cooperates with Mutant KRAS to Drive Invasive Mucinous Adenocarcinoma of the Lung.

Koichi Tomoshige William D Stuart Iris M Fink-Baldauf Masaoki Ito Tomoshi Tsuchiya Takeshi Nagayasu Tomoki Yamatsuji Morihito Okada Takuya Fukazawa Minzhe Guo Yutaka Maeda

Published in: Cancer research (2023)

FOXA2 expression combined with mutant KRAS drives invasive mucinous adenocarcinoma of the lung by synergistically promoting a mucous transcriptional program, suggesting strategies for targeting this lung cancer type that lacks effective therapies.

Keyphrases

wild type
low grade
squamous cell carcinoma
poor prognosis
locally advanced
gene expression
quality improvement
cancer therapy
transcription factor
high grade
heat shock