Determination of the optimal diabetes duration for bone regeneration experiments in an alloxan-induced diabetic rabbit calvarial defect model.

Sang-Hun Jeong Bo Hyun Jung Ki-Yeon Yoo Heung-Sik Um Beom-Seok Chang Jae-Kwan Lee Won-Youl Choi

Published in: Journal of periodontal & implant science (2018)

ALX administration at 100 mg/kg successfully induced experimental diabetes in rabbits. The effect of diabetes on bone healing was evident when the interval between diabetes induction and the intervention was ≥1 week.

Keyphrases

type diabetes
bone regeneration
cardiovascular disease
glycemic control
randomized controlled trial
high glucose
diabetic rats
drug induced
bone mineral density
clinical trial
oxidative stress
metabolic syndrome
skeletal muscle
soft tissue
mass spectrometry
body composition
weight loss
placebo controlled