Oncogenic and tumor suppressor genes expression in myeloproliferative neoplasms: The hidden side of a complex pathology.
Elham AbediMehran KarimiRamin YaghobiHamid MohammadiSezaneh HaghpanahMohamad MoghadamElahe BayatAlireza RezvaniMani RamziPublished in: Journal of clinical laboratory analysis (2022)
Chronic myeloid leukemia cases showed a significant upregulation of WNT5B, as a known oncogenesis gene. Two tumor suppressor genes, namely DCC and CMTM5, were downregulated in the patients with MPNs, especially in females and patients below 60 years of age.
Keyphrases
- genome wide
- chronic myeloid leukemia
- poor prognosis
- end stage renal disease
- genome wide identification
- cell proliferation
- ejection fraction
- newly diagnosed
- chronic kidney disease
- stem cells
- transcription factor
- peritoneal dialysis
- prognostic factors
- signaling pathway
- genome wide analysis
- dna methylation
- patient reported outcomes
- patient reported