Genetic animal modeling for idiopathic scoliosis research: history and considerations.

Elizabeth A TerhuneAnna M MonleyMelissa T CuevasCambria I WetheyRyan S GrayNancy Hadley-Miller

Published in: Spine deformity (2022)

We advocate careful selection of animal models based on the scientific question and introduce gaps and limitations in the current literature. We advocate future research efforts to include animal models with multiple characterized genetic or environmental perturbations to reflect current understanding of the human condition.

Keyphrases

genome wide
endothelial cells
systematic review
copy number
induced pluripotent stem cells
current status
pluripotent stem cells
quality improvement
dna methylation
gene expression