APOE traffics to astrocyte lipid droplets and modulates triglyceride saturation and droplet size.

Ian A WindhamJoey V RagusaE Diane WallaceColby H WagnerKristen K WhiteStephanie M Cohen

Published in: bioRxiv : the preprint server for biology (2023)

. discover that APOE in astrocytes can traffic to lipid droplets (LDs), where it modulates LD composition and size. Astrocytes expressing the Alzheimer's risk variant APOE4 form large LDs with impaired turnover and increased peroxidation sensitivity.

Keyphrases

cognitive decline
high fat diet
mild cognitive impairment
fatty acid
air pollution
high throughput
adipose tissue
single cell
insulin resistance
skeletal muscle