Identification of the Transcriptional Networks and the Involvement in Angiotensin II-Induced Injury after CRISPR/Cas9-Mediated Knockdown of Cyr61 in HEK293T Cells.

Junjie Wang Dongdong Fu Soulixay Senouthai Yan Jiang Rentong Hu Yan-Wu You

Published in: Mediators of inflammation (2019)

The Cyr61 gene is involved in Ang II-induced injury in HEK293T cells. Functional mechanisms of the differentially expressed lncRNAs and mRNAs as well as identification of metabolic pathways will provide new therapeutic targets for Cyr61-realated diseases.

Keyphrases

angiotensin ii
crispr cas
high glucose
diabetic rats
angiotensin converting enzyme
vascular smooth muscle cells
genome editing
drug induced
transcription factor
oxidative stress
copy number
endothelial cells
bioinformatics analysis
genome wide