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Analyses of allele age and fitness impact reveal human beneficial alleles to be older than neutral controls.

Alyssa M PivirottoAlexander PlattRavi PatelSudhir KumarJody Hey
Published in: bioRxiv : the preprint server for biology (2023)
Analyses of allele age and evolutionary impact reveal that beneficial alleles in a human population are often older than neutral controls, suggesting a large role for balancing selection in adaptation.
Keyphrases
  • endothelial cells
  • physical activity
  • genome wide
  • induced pluripotent stem cells
  • pluripotent stem cells
  • middle aged
  • single cell
  • body composition
  • dna methylation