Epigenetic tuning of brain signal entropy in emergent human social behavior.
Meghan H PugliaKathleen M KrolManuela MissanaCabell L WilliamsTravis S LillardJames P MorrisJessica J ConnellyTobias GrossmannPublished in: BMC medicine (2020)
Demonstrating these associations in infancy is critical for elucidating the neurobiological mechanisms accounting for individual differences in cognition and behavior relevant to neurodevelopmental disorders. Our results suggest that an epigenetic modification to the oxytocin receptor gene and brain signal entropy are useful indicators of social development and may hold potential diagnostic, therapeutic, and prognostic value.
Keyphrases
- white matter
- dna methylation
- healthcare
- resting state
- gene expression
- mental health
- endothelial cells
- genome wide
- multiple sclerosis
- cerebral ischemia
- copy number
- mild cognitive impairment
- induced pluripotent stem cells
- risk assessment
- climate change
- body mass index
- blood brain barrier
- pluripotent stem cells
- transcription factor
- genome wide identification