Combinatorial Inactivation of Tumor Suppressors Efficiently Initiates Lung Adenocarcinoma with Therapeutic Vulnerabilities.
Maryam YousefiGábor BorossCarly WeissChristopher W MurrayJess D HebertHongchen CaiEmily L AshkinSaswati KarmakarLaura AndrejkaLeo ChenMinwei WangMin K TsaiWen-Yang LinChuan LiPegah YakhchalianCaterina I ColónSu-Kit ChewPauline ChuCharles SwantonChristian A KunderDmitri A PetrovMonte M WinslowPublished in: Cancer research (2022)
To address the large fraction of lung adenocarcinomas lacking mutations in proto-oncogenes for which targeted therapies are unavailable, this work uncovers driver pathways of oncogene-negative lung adenocarcinomas and demonstrates their therapeutic vulnerabilities.
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