Alterations in cerebral and cardiac mitochondrial function in a porcine model of acute carbon monoxide poisoning.
David H JangSarah PielJohn C GreenwoodMatthew KellyVanessa M MazandiAbhay RanganathanYuxi LinJonathan StarrThomas HallowellFrances S ShoferWesley B BakerAlec LafontantKristen AndersenJohannes K EhingerTodd J KilbaughPublished in: Clinical toxicology (Philadelphia, Pa.) (2021)
Low-dose CO poisoning is associated with early mitochondrial disruption prior to an observable phenotype highlighting the important role of mitochondrial function in the pathology of CO poisoning. This may represent an important intervenable pathway for therapy and intervention.
Keyphrases
- low dose
- randomized controlled trial
- liver failure
- oxidative stress
- respiratory failure
- high dose
- subarachnoid hemorrhage
- left ventricular
- drug induced
- stem cells
- heart failure
- aortic dissection
- atrial fibrillation
- brain injury
- hepatitis b virus
- cerebral ischemia
- extracorporeal membrane oxygenation
- mechanical ventilation
- blood brain barrier
- replacement therapy