Secondary structure of the human mitochondrial genome affects formation of deletions.
Victor ShamanskiyAlina A MikhailovaEvgenii O TretiakovKristina UshakovaAlina G MikhailovaSergei OreshkovDmitry A KnorreNatalia ReeJonathan B OverdevestSamuel W LukowskiIrina GostimskayaValerian YurovChia-Wei LiouTsu-Kung LinWolfram S KunzAlexandre ReymondIlya MazuninGeorgii A BazykinJacques FellayMasashi TanakaKonstantin KhrapkoKonstantin GunbinKonstantin PopadinPublished in: BMC biology (2023)
Overall, we provide topological insights into the mechanism of age-associated deletion formation in human mtDNA, which could be used to predict somatic deletion burden and maximum lifespan in different human haplogroups and mammalian species.