Diet-induced iron deficiency in rats impacts small intestinal calcium and phosphate absorption.
Evans O AsowataOluwatobi OlusanyaKaoutar AbaakilHavovi ChichgerSurjit K S SraiRobert J UnwinJoanne MarksPublished in: Acta physiologica (Oxford, England) (2021)
We propose that iron deficiency alters calcium and phosphate transport in the duodenum. This occurs via changes to the paracellular pathway, whereby upregulation of claudin 2 increases calcium absorption and upregulation of claudin 3 inhibits phosphate absorption.