Brown adipose tissue prevents glucose intolerance and cardiac remodeling in high-fat-fed mice after a mild myocardial infarction.
Carmem Peres Valgas da SilvaVikram K ShettigarLisa A BaerEaman AbayKendra L MadarisMikayla R MehlingDiego Hernandez-SaavedraKelsey M PinckardNickolai P SeculovMark T ZioloKristin I StanfordPublished in: International journal of obesity (2005) (2021)
BAT transplantation prevents IGT, the increase in LVM, and exercise intolerance following MI. MI alters the expression of several metabolic-related genes in WAT and liver in Sham-MI mice, suggesting that these tissues may contribute to the impaired metabolic response. Increasing BAT may be an important intervention to prevent the development of IGT or T2D and cardiac remodeling in obese patients post-MI.
Keyphrases
- obese patients
- adipose tissue
- left ventricular
- bariatric surgery
- high fat diet induced
- poor prognosis
- insulin resistance
- gastric bypass
- heart failure
- roux en y gastric bypass
- mouse model
- gene expression
- high fat diet
- blood glucose
- metabolic syndrome
- stem cells
- clinical trial
- resistance training
- blood pressure
- type diabetes
- long non coding rna
- wild type
- glycemic control