The Circ_35953 induced by the NF-κB mediated the septic AKI via targeting miR-7219-5p/HOOK3 and IGFBP7 axis.
Yuqing FengBohao LiuJinwen ChenHuiling LiDongshan ZhangPublished in: Journal of cellular and molecular medicine (2023)
A few studies suggested that CircRNAs were involved in the development of septic AKI. However,the role and regulation mechanism of CircRNA_35953 in septic AKI remains unclear. Here, we found that Circ_35953 was induced by LPS via activation of NF-κB signal in BUMPT cells. Functionally, Circ_35953 mediated the LPS induced the apoptosis in BUMPT cells. Moreover, we demonstrated that Circ_35953 sponged miR-7219-5p to upregulate the expression of HOOK3 and IGFBP7. Finally, we verified that knock down of Circ_35953 alleviated the progression of CLP-induced AKI via targeting the miR-7219-5p/HOOK3 and IGFBP7 signal. Collectively, the data suggested that Circ_35953 /miR-7219-5p/HOOK3 and IGFBP7 axis mediated the septic AKI, which also revealed a potential mechanism of septic AKI.
Keyphrases
- acute kidney injury
- lps induced
- cell cycle arrest
- inflammatory response
- induced apoptosis
- pi k akt
- signaling pathway
- oxidative stress
- cell death
- endoplasmic reticulum stress
- poor prognosis
- nuclear factor
- single cell
- machine learning
- long non coding rna
- drug delivery
- cell proliferation
- endothelial cells
- immune response
- binding protein
- deep learning
- data analysis