Transcriptome analysis of IPF fibroblastic foci identifies key pathways involved in fibrogenesis.
Delphine GuillotinAdam R TaylorManuela PlatéPaul F MercerLindsay M EdwardsRoss HaggartGino MieleRobin J McAnultyToby M MaherRobert Edward HyndsMariam Jamal-HanjaniRichard P MarshallAndrew J FisherAndy D BlanchardRachel C ChambersPublished in: Thorax (2020)
These data provide strong support for the human tissue-based and bioinformatics approaches adopted to identify critical transcriptional nodes associated with the key pathogenic cell responsible for fibrogenesis in situ and further identify the TSC2/RHEB axis as a potential novel target for interfering with excessive matrix deposition in IPF and other fibrotic conditions.
Keyphrases
- idiopathic pulmonary fibrosis
- endothelial cells
- single cell
- induced pluripotent stem cells
- genome wide
- cell therapy
- gene expression
- electronic health record
- pluripotent stem cells
- sentinel lymph node
- weight gain
- systemic sclerosis
- stem cells
- squamous cell carcinoma
- machine learning
- early stage
- body mass index
- human health
- physical activity
- rectal cancer
- deep learning
- locally advanced