Genome-wide CRISPR screen reveals PSMA6 to be an essential gene in pancreatic cancer cells.

Jesse BakkeWilliam C WrightAnthony E ZamoraPeter OladimejiJeremy Chase CrawfordChristopher T BrewerRobert J AutryWilliam E EvansPaul G ThomasTaosheng Chen

Published in: BMC cancer (2019)

Further study of PSMA6 and the proteasome subunit that it encodes, along with other hits identified in our CRISPR screens, may provide valuable insights into potential therapeutic targets for PDAC.

Keyphrases

genome wide
dna methylation
pet ct
copy number
pet imaging
crispr cas
genome editing
gene expression
human health
risk assessment
computed tomography