Retinal angiotensin II and angiotensin-(1-7) response to hyperglycemia and an intervention with captopril.
Preenie deS SenanayakeVera L BonilhaJohn W PetersonYoshiro YamadaSadashiva S KarnikFirouz DaneshgariK Bridget BrosnihanJoe G HollyfieldPublished in: Journal of the renin-angiotensin-aldosterone system : JRAAS (2019)
These studies reveal that pharmacological inhibition with ACEIs may provide a specific intervention for the management of the diabetes-induced decline in retinal function, reversing the profile of the endogenous angiotensin peptides closer to the normal condition.
Keyphrases
- angiotensin ii
- angiotensin converting enzyme
- optical coherence tomography
- randomized controlled trial
- vascular smooth muscle cells
- diabetic retinopathy
- diabetic rats
- type diabetes
- cardiovascular disease
- optic nerve
- high glucose
- oxidative stress
- genome wide
- drug induced
- glycemic control
- gene expression
- single cell
- metabolic syndrome
- case control
- dna methylation
- skeletal muscle
- stress induced