Association of Circulating Neutrophils with Relative Volume of Lipid-Rich Necrotic Core of Coronary Plaques in Stable Patients: A Substudy of SMARTool European Project.
Silverio SbranaAntonella CecchettiniLuca BastianiAnnamaria MazzoneFederico VozziChiara CaselliDanilo NegliaAlberto ClementeArthur J H A ScholteOberdan ParodiGualtiero PelosiSilvia RocchiccioliPublished in: Life (Basel, Switzerland) (2023)
These preliminary findings suggest that a sustained increase in circulating neutrophils, together with the up-regulation of the integrin/activation membrane neutrophil marker CD11b may contribute, through the progressive intra-plaque accumulation of necrotic/apoptotic cells exceeding the efferocytosis/anti-inflammatory capacity of infiltrating macrophages and lymphocytes, to the relative enlargement of the lipid-rich necrotic core volume of coronary plaques in stable CAD patients, thus increasing their individual risk of acute complication.
Keyphrases
- end stage renal disease
- coronary artery disease
- ejection fraction
- chronic kidney disease
- newly diagnosed
- anti inflammatory
- coronary artery
- peritoneal dialysis
- multiple sclerosis
- heart failure
- cell death
- aortic stenosis
- induced apoptosis
- fatty acid
- intensive care unit
- patient reported outcomes
- quality improvement
- aortic valve
- cell cycle arrest
- patient reported