A Plant-Derived Antioxidant Supplement Prevents the Loss of Retinal Ganglion Cells in the Retinas of NMDA-Injured Mice.

Shigeto MaekawaKota SatoTaiki KokubunNoriko HimoriTakeshi YabanaMichiko Ohno-OishiGe ShiKazuko OmodakaToru Nakazawa

Published in: Clinical ophthalmology (Auckland, N.Z.) (2022)

suppressed RGC death. This oral supplementation decreased lipid oxidation and excessive calpain activation in NMDA-injured retinas. Thus, our newly developed antioxidant supplement has a potential role in neuroprotective treatment for retinal diseases, such as glaucoma.

Keyphrases

oxidative stress
induced apoptosis
anti inflammatory
cell cycle arrest
optic nerve
optical coherence tomography
diabetic retinopathy
high fat diet induced
type diabetes
cell death
fatty acid
signaling pathway
skeletal muscle
brain injury