Role of autoantibody levels as biomarkers in the management of patients with myasthenia gravis: A systematic review and expert appraisal.
Andreas MeiselFulvio BaggiAnthony BehinAmelia EvoliAnna Kostera-PruszczykRenato MantegazzaRaul Juntas MoralesAnna Rostedt PungaSabrina SacconiMichael SchroeterJan J G M VerschuurenLouise CrathorneKris HolmesMaria-Isabel LeitePublished in: European journal of neurology (2022)
This first SLR to assess whether a correlation exists between autoantibody levels and disease activity in patients with MG has indicated a potential positive correlation, which could have clinical implications in guiding treatment decisions. However, in light of the limited and variable evidence, we cannot currently recommend routine clinical use of autoantibody level testing in this context. For now, patient's characteristics, clinical disease course, and laboratory data (e.g., autoantibody status, thymus histology) should inform management, alongside patient-reported outcomes. We highlight the need for future studies to reach more definitive conclusions on this relationship.
Keyphrases
- disease activity
- patient reported outcomes
- rheumatoid arthritis
- systemic lupus erythematosus
- myasthenia gravis
- rheumatoid arthritis patients
- ankylosing spondylitis
- clinical practice
- juvenile idiopathic arthritis
- electronic health record
- squamous cell carcinoma
- current status
- locally advanced
- deep learning
- big data