Frem1 activity is regulated by Sonic Hedgehog signaling in the cranial neural crest mesenchyme during midfacial morphogenesis.

Matthew T McLaughlinMiranda R SunTyler G BeamesAustin C StewardJoshua W M TheisenHannah M ChungJoshua L EversonIvan P MoskowitzMichael D SheetsRobert J Lipinski

Published in: Developmental dynamics : an official publication of the American Association of Anatomists (2022)

By demonstrating that the Shh signaling pathway regulates Frem1 expression in cNCCs, these findings provide novel insight into the mechanisms underlying variation in midfacial morphogenesis. This article is protected by copyright. All rights reserved.

Keyphrases

signaling pathway
poor prognosis
pi k akt
epithelial mesenchymal transition
binding protein
induced apoptosis
long non coding rna
oxidative stress
cell proliferation