High-dose chemotherapy followed by autologous hematopoietic stem cell transplantation is considered the standard of care for multiple myeloma patients who are eligible for transplantation. The process of autografting comprises the following steps: control of the primary disease by using a certain induction therapeutic protocol, mobilization of stem cells, collection of mobilized stem cells by apheresis, cryopreservation of the apheresis product, administration of high-dose pretransplant conditioning therapy, and finally infusion of the cryopreserved stem cells after thawing. However, in cancer centers that treat patients with multiple myeloma and have transplantation capabilities but lack or are in the process of acquiring cryopreservation facilities, alternatively noncryopreserved autologous stem cell therapy has been performed with remarkable success as the pretransplant conditioning therapy is usually brief.
Keyphrases
- cell therapy
- stem cells
- multiple myeloma
- high dose
- low dose
- end stage renal disease
- stem cell transplantation
- mesenchymal stem cells
- acute myeloid leukemia
- randomized controlled trial
- ejection fraction
- newly diagnosed
- chronic kidney disease
- healthcare
- prognostic factors
- peripheral blood
- papillary thyroid
- palliative care
- umbilical cord
- quality improvement
- bone marrow
- squamous cell
- locally advanced
- cord blood
- chronic pain
- young adults