Epithelial to mesenchymal transition (EMT) is associated with attenuation of succinate dehydrogenase (SDH) in breast cancer through reduced expression of SDHC.
Gro V RøslandSissel E DyrstadDeusdedit TusubiraReham HelwaTuan Zea TanMaria L LotsbergIna K N PettersenAnna BergCharlotte KindtFredrik HoelKirstine JacobsenAri J ArasonAgnete S T EngelsenHenrik J DitzelPer E LønningCamilla KrakstadJean P ThieryJames B LorensStian KnappskogKarl Johan TronstadPublished in: Cancer & metabolism (2019)
Our findings suggest that downregulation of SDHC promotes EMT and that this is accompanied by structural remodeling of the mitochondrial organelles. This may confer survival benefits upon exposure to hostile microenvironment including oxidative stress and hypoxia during cancer progression.
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