Broad-spectrum RNA antiviral inspired by ISG15 -/- deficiency.
Yemsratch T AkaluRoosheel S PatelJustin TaftRodrigo Cañas-ArranzAshley RichardsonSofija ButaMarta Martin-FernandezChristos SazeidesRebecca L PearlGayatri MainkarAndrew P KurlandRachel GeltmanHaylen RosbergerDiana D KangAnn Anu KurianKeerat KaurJennie AltmanYizhou DongJeffrey R JohnsonLior ZhangiJean K LimRandy A AlbrechtAdolfo García-SastreBrad R RosenbergDusan BogunovicPublished in: bioRxiv : the preprint server for biology (2024)
Human inborn error of immunity-guided discovery and development of a broad-spectrum RNA antiviral therapy.