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Characterising 24-h skeletal muscle gene expression alongside metabolic & endocrine responses under diurnal conditions.

Harry A SmithIain TemplemanMax DavisTommy SlaterDavid J ClaytonIan VarleyLewis J JamesBenita MiddletonJonathan D JohnstonLeonidas G KaragounisKostas TsintzasDylan ThompsonJavier T GonzalezJean-Philippe WalhinJames Alexander Betts
Published in: The Journal of clinical endocrinology and metabolism (2024)
Diurnal rhythms were present in human skeletal muscle gene expression as well systemic metabolites and hormones under controlled diurnal conditions. The temporal patterns of genes relating to carbohydrate and lipid metabolism alongside circulating insulin are consistent with diurnal rhythms being driven in part by the diurnal influence of cyclic feeding and fasting.
Keyphrases
  • gene expression
  • skeletal muscle
  • insulin resistance
  • dna methylation
  • type diabetes
  • endothelial cells
  • ms ms
  • adipose tissue
  • blood pressure
  • fatty acid