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Transcriptional upregulation of multiple earthworm chitinase genes following bacterial challenge suggests their implications in innate immunity.

Beom Jun ParkYoo Bin YoonDong Ho LeeChuog ShinLouis JuakaliSung-Jin ChoSoon Cheol Park
Published in: Genes & genomics (2021)
To our knowledge, this is the first report providing direct evidence that multiple earthworm chitinases are bacteria-responsive, strongly suggesting that earthworm chitinases are inducible humoral effectors in earthworm innate immunity. In addition, our results possibly suggest that earthworm EaChi4 may function as a pattern recognition molecule modulating the downstream immune pathway.
Keyphrases
  • immune response
  • signaling pathway
  • healthcare
  • gene expression
  • transcription factor
  • poor prognosis
  • cell proliferation
  • genome wide
  • cancer therapy
  • genome wide identification