Preservation of lymphocyte functional fitness in perinatally-infected and treated HIV+ pediatric patients displaying sub-optimal viral control.
Aaruni KhanolkarWilliam J MullerBridget M SimpsonJillian CerulloRuth WilliamsSun Bae SowersKiana MatthewsSara MercaderCarole J HickmanRichard T D'AquilaGuorong LiuPublished in: Communications medicine (2022)
These results highlight the immune resilience in HIV+ children on ART with sub-optimal viral control. With respect to HIV+ children on ART with better viral control, our data suggest that this cohort might potentially benefit from targeted interventions that might mitigate cell-mediated immune functional quiescence.
Keyphrases
- antiretroviral therapy
- hiv infected
- hiv positive
- human immunodeficiency virus
- hiv aids
- hiv testing
- sars cov
- hepatitis c virus
- young adults
- men who have sex with men
- physical activity
- single cell
- body composition
- south africa
- cell therapy
- social support
- stem cells
- peripheral blood
- mesenchymal stem cells
- artificial intelligence
- drug delivery
- big data