Proteomic analysis of serum samples of paracoccidioidomycosis patients with severe pulmonary sequel.
Amanda Ribeiro Dos SantosAline DionizioMileni da Silva FernandesMarília Afonso Rabelo BuzalafBeatriz Aparecida Soares PereiraDébora de Fátima Almeida DonanzamSergio Ribeiro MarroneAnamaria Mello Miranda PaniagoRicardo de Souza CavalcanteRinaldo Pôncio MendesJames VenturiniPublished in: PLoS neglected tropical diseases (2021)
Development of severe PS is related to increased expression of proteins involved in glycolytic pathway and oxygen exchange), indicative of the greater cellular activity and replication associated with early dysregulation of wound healing and aberrant tissue repair. Our findings provide new targets to study mechanisms of PS in PCM, as well as potential biomarkers.