IFN-γ and LPS Induce Synergistic Expression of CCL2 in Monocytic Cells via H3K27 Acetylation.
Nadeem AkhterShihab KochumonAmal HasanAjit WilsonRasheeba NizamAshraf Al MadhounFatema Al-RashedHossein ArefanianFawaz AlzaidSardar SindhuFahd Al-MullaRasheed AhmadPublished in: Journal of inflammation research (2022)
Our findings suggest that IFN-γ, in combination with LPS, has the potential to augment inflammation via the H3K27ac-mediated induction of CCL2 in monocytic cells in the setting of obesity.
Keyphrases
- induced apoptosis
- cell cycle arrest
- inflammatory response
- oxidative stress
- type diabetes
- dendritic cells
- poor prognosis
- metabolic syndrome
- insulin resistance
- endoplasmic reticulum stress
- signaling pathway
- cell death
- liver injury
- liver fibrosis
- weight gain
- adipose tissue
- long non coding rna
- cancer therapy
- pi k akt
- skeletal muscle