The association between visceral adiposity with systemic inflammation, oxidative stress, and risk of post-surgical adhesion.
Mohammad-Hassan ArjmandPublished in: Archives of physiology and biochemistry (2020)
Abdominal and pelvic adhesions are common post-operative complications. Despite new medical technologies, these adhesions are appearing to be unavoidable and little is known about their causation; for example, why certain patients/or tissues are more prone to adhesions. There have been no clinical studies about increasing the risk adhesions in obese patients, but there is some evidence about the molecular mechanisms involving visceral fat (VF) that may lead to profibrotic conditions. VF is an endocrine/inflammatory organ which produces many biologically active molecules such as adipokines and inflammatory cytokines. Inflammatory conditions, oxidative stress, and the expression some fibrotic molecules in the VF may induce pathological conditions in the abdominal cavity that predispose to the formation of fibrotic bands.
Keyphrases
- oxidative stress
- obese patients
- insulin resistance
- bariatric surgery
- dna damage
- newly diagnosed
- systemic sclerosis
- ischemia reperfusion injury
- diabetic rats
- idiopathic pulmonary fibrosis
- adipose tissue
- ejection fraction
- poor prognosis
- healthcare
- induced apoptosis
- gastric bypass
- gene expression
- roux en y gastric bypass
- prognostic factors
- risk factors
- rectal cancer
- patient reported outcomes
- type diabetes
- escherichia coli
- weight loss
- body mass index
- heat shock
- cystic fibrosis
- staphylococcus aureus
- cell migration