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MicroRNA-5010-5p ameliorates high-glucose induced inflammation in renal tubular epithelial cells by modulating the expression of PPP2R2D.

Sunghee ChoiMithun Kumer SarkerMi Ra YuHaekyung LeeSoon Hyo KwonJin Seok JeonHyunjin NohHyoungnae Kim
Published in: BMJ open diabetes research & care (2024)
Our findings suggest that increased miR-5010-5p expression reduces high glucose-induced inflammatory responses in renal tubular epithelial cells via the regulation of the target gene, PPP2R2D, which modulates AMPK phosphorylation. Therefore, miR-5010-5p may be a promising therapeutic target for DKD.
Keyphrases
  • high glucose
  • endothelial cells
  • poor prognosis
  • oxidative stress
  • binding protein
  • skeletal muscle
  • signaling pathway
  • mouse model
  • long non coding rna
  • gene expression
  • genome wide analysis