GMP-compliant extracellular vesicles derived from umbilical cord mesenchymal stromal cells: manufacturing and pre-clinical evaluation in ARDS treatment.

Zaquer Suzana Munhoz Costa-FerroGisele Vieira RochaKatia Nunes da SilvaBruno Diaz ParedesErick Correia LoiolaJohnatas Dutra SilvaJohn Lenon de Souza SantosRosane Borges DiasCláudio Pereira FigueiraCamila Indiani de OliveiraLudmilla David de MouraLígia Nunes de Morais RibeiroEneida de PaulaDalila Lucíola ZanetteClarissa Araújo Gurgel RochaPatricia Rieken Macedo RoccoBruno Solano de Freitas Souza

Published in: Cytotherapy (2024)

hUCMSC-EVs were successfully obtained following a cGMP-compliant protocol, with consistent characteristics and pre-clinical safety profile, supporting their future clinical development as cell-free therapies.

Keyphrases

cell free
umbilical cord
clinical evaluation
mesenchymal stem cells
randomized controlled trial
bone marrow
acute respiratory distress syndrome
current status
circulating tumor
cystic fibrosis