Recovery of Cardiac Remodeling and Dysmetabolism by Pancreatic Islet Injury Improvement in Diabetic Rats after Yacon Leaf Extract Treatment.
Klinsmann Carolo Dos SantosSarah Santiloni CuryAna Paula Costa Rodrigues FerrazJose Eduardo CorrenteBianca Mariani GonçalvesLuiz Henrique de Araújo MachadoRobson Francisco CarvalhoAna Cláudia de Melo Stevanato NakamuneAlexandre Todorovic FabroPaula Paccielli FreireCamila Renata CorrêaPublished in: Oxidative medicine and cellular longevity (2018)
Yacon (Smallanthus sonchifolius) is a native Andean plant rich in phenolic compounds, and its effects on dysmetabolism and cardiomyopathy in diabetic rats was evaluated. The rats (10/group) were allocated as follows: C, controls; C + Y, controls treated with Yacon leaf extract (YLE); DM, diabetic controls; and DM + Y, diabetic rats treated with YLE. Type 1 diabetes (T1DM) was induced by the administration of streptozotocin (STZ; 40 mg-1/kg body weight, single dose, i.p.), and treated groups received 100 mg/kg body weight YLE daily via gavage for 30 d. The YLE group shows an improvement in dysmetabolism and cardiomyopathy in the diabetic condition (DM versus DM + Y) promoting a significant reduction of glycemia by 63.39%, an increase in insulin concentration by 49.30%, and a decrease in serum triacylglycerol and fatty acid contents by 0.39- and 0.43-fold, respectively, by ameliorating the pancreatic islet injury, as well as increasing the activity of the antioxidant enzymes (catalase, superoxide dismutase, and glutathione peroxidase) and decreasing the fibrosis and cellular disorganization in cardiac tissue. The apparent benefits of YLE seem to be mediated by ameliorating dysmetabolism and oxidative stress in pancreatic and cardiac tissues.
Keyphrases
- diabetic rats
- oxidative stress
- body weight
- type diabetes
- glycemic control
- left ventricular
- dna damage
- fatty acid
- heart failure
- induced apoptosis
- ischemia reperfusion injury
- insulin resistance
- gene expression
- cardiovascular disease
- wound healing
- heat shock
- magnetic resonance imaging
- computed tomography
- metabolic syndrome
- weight loss
- newly diagnosed
- atrial fibrillation
- adipose tissue
- magnetic resonance
- endoplasmic reticulum stress
- anti inflammatory
- smoking cessation