Recommendations for evaluation and diagnosis of extra-glandular manifestations of primary Sjögren syndrome: results of an epidemiologic systematic review/meta-analysis and a consensus guideline from the Brazilian society of rheumatology (hepatic, gastrointestinal and pancreatic).
Virgínia Fernandes Moça TrevisaniAysa César PinheiroSonia Cristina de Magalhães Souza FialhoMarilena Leal Mesquita Silvestre FernandesAlisson PugliesiSandra Gofinet PasotoMaria Lucia Lemos LopesLissiane Karine Noronha GuedesSamira Tatiyama MiyamotoLaura Caldas Dos SantosSimone AppenzellerTania FidelixSandra Lucia Euzébio RibeiroDanielle Christinne Soares Egypto de BritoTatiana Nayara Libório-KimuraMaria Carmen Lopes Ferreira Silva SantosDiego Ustárroz CantaliJuliana D 'Agostino GennariKarina Gatz CapobiancoVinicius Tassoni CivileAna Carolina Pereira Nunes PintoAline Pereira da RochaCésar Ramos Rocha-FilhoFabiola Reis OliveiraValeria ValimPublished in: Advances in rheumatology (London, England) (2022)
Sjogren's syndrome (SS) is an autoimmune disease characterized by lymphocytic infiltration of the exocrine glands and other organs, associated with sicca syndrome but also with systemic involvement with varying degrees of severity. Despite their importance, some systemic manifestations, mainly liver, gastrointestinal, and pancreatic are not routinely evaluated. To address these manifestations, the Sjögren's Syndrome Committee of the Brazilian Society of Rheumatology conducted a broad systematic review of the literature on studies investigating prevalence and diagnosis of these symptoms in Sjogren´s patients and made recommendations based on the findings. Agreement between the experts was achieved using the Delphi method. This is the second part of this guideline, providing 6 recommendations for liver, gastrointestinal, and pancreatic care of SS patients.