Statins Prevent the Deleterious Consequences of Placental Chemerin Upregulation in Preeclampsia.
Lunbo TanAnna C M KluiversEdwyn O Cruz-LópezMichelle BroekhuizenZhongli ChenRugina I NeumanSam SchoenmakersElisabeth J RuijgrokDaan van de VeldeBrenda C M de WinterAntoon J van den BogaerdtXifeng LuAlexander H J DanserKoen VerdonkPublished in: Hypertension (Dallas, Tex. : 1979) (2024)
Chemerin is a biomarker for preeclampsia, and statins both prevent its placental upregulation and effects, in an NO and low-density lipoprotein receptor-dependent manner. Combined with their capacity to improve the sFlt-1/PlGF ratio, this offers an attractive mechanism by which statins may prevent or treat preeclampsia.