Effectiveness of Curcumin on Outcomes of Hospitalized COVID-19 Patients: A Systematic Review of Clinical Trials.
Amir Vahedian-AzimiMitra AbbasifardFarshid Rahimi-BasharPaul C GuestMuhammed MajeedAsadollah MohammadiMaciej BanachTannaz JamialahmadiAmir Hossein SahebkarPublished in: Nutrients (2022)
Despite the ongoing vaccination efforts, there is still an urgent need for safe and effective treatments to help curb the debilitating effects of COVID-19 disease. This systematic review aimed to investigate the efficacy of supplemental curcumin treatment on clinical outcomes and inflammation-related biomarker profiles in COVID-19 patients. We searched PubMed, Scopus, Web of Science, EMBASE, ProQuest, and Ovid databases up to 30 June 2021 to find studies that assessed the effects of curcumin-related compounds in mild to severe COVID-19 patients. Six studies were identified which showed that curcumin supplementation led to a significant decrease in common symptoms, duration of hospitalization and deaths. In addition, all of these studies showed that the intervention led to amelioration of cytokine storm effects thought to be a driving force in severe COVID-19 cases. This was seen as a significant ( p < 0.05) decrease in proinflammatory cytokines such as IL1β and IL6, with a concomitant significant ( p < 0.05) increase in anti-inflammatory cytokines, including IL-10, IL-35 and TGF-α. Taken together, these findings suggested that curcumin exerts its beneficial effects through at least partial restoration of pro-inflammatory/anti-inflammatory balance. In conclusion, curcumin supplementation may offer an efficacious and safe option for improving COVID-19 disease outcomes. We highlight the point that future clinical studies of COVID-19 disease should employ larger cohorts of patients in different clinical settings with standardized preparations of curcumin-related compounds.
Keyphrases
- sars cov
- coronavirus disease
- systematic review
- clinical trial
- randomized controlled trial
- respiratory syndrome coronavirus
- anti inflammatory
- oxidative stress
- ejection fraction
- public health
- meta analyses
- early onset
- physical activity
- patient reported
- metabolic syndrome
- signaling pathway
- quality improvement
- sleep quality
- study protocol
- machine learning
- artificial intelligence
- single molecule
- double blind
- smoking cessation
- replacement therapy