A randomized translational study on protein- and glucose metabolism in skeletal muscles evaluated by gene-ontology, following preoperative oral carbohydrate loading compared to overnight peripheral parenteral nutrition (PPN) before major cancer surgery.
Britt-Marie IresjöUlrika SmedhCecilia EngströmJan PerssonChristian MårtenssonKent LundholmPublished in: Journal of translational medicine (2024)
Conventional overnight preoperative PPN seems effective to induce and support improved muscle protein metabolism in patients aimed at major cancer surgery while preoperative oral carbohydrate loading, according to ERAS-protocols, was ineffective to improve skeletal muscle catabolism and should therefore not be recommended before major cancer surgery. Trial registration Clinical trials.gov: NCT05080816, Registered June 10th 2021- Retrospectively registered. https://clinicaltrials.gov/study/NCT05080816.
Keyphrases
- papillary thyroid
- minimally invasive
- skeletal muscle
- clinical trial
- coronary artery bypass
- patients undergoing
- squamous cell
- end stage renal disease
- ejection fraction
- chronic kidney disease
- newly diagnosed
- adipose tissue
- lymph node metastasis
- prognostic factors
- protein protein
- genome wide
- metabolic syndrome
- dna methylation
- randomized controlled trial
- phase iii
- peritoneal dialysis
- binding protein
- genome wide identification
- double blind
- patient reported